Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed.This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses.An iDNA vaccine uses plasmid DNA to launch live-attenuated virus vaccines in vitro or in vivo.When iDNA is injected into mammalian cell
Sapindus saponaria L.é uma árvore de grande porte distribuída especialmente na região Amazônica, sendo de grande importância para o reflorestamento de áreas degradadas, na construção civil e confecção de brinquedos.O objetivo dessa pesquisa foi testar tratamentos pré-germinativos para superar a dormência e avaliar o efeito da temperatu
Elucidating protective immunity against HCV is important for the development of a preventative vaccine.We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affects the quality and quantity of HCV-specific T cell responses.To test these hypotheses, we performed T cell epit